{"id":3764,"date":"2014-01-01T19:13:19","date_gmt":"2014-01-01T18:14:32","guid":{"rendered":"http:\/\/antidote-europe.org\/?page_id=3764"},"modified":"2020-12-28T05:18:59","modified_gmt":"2020-12-28T03:18:59","slug":"danger-bisphenol","status":"publish","type":"page","link":"https:\/\/antidote-europe.eu\/en\/danger-bisphenol\/","title":{"rendered":"Danger Bisphenol !"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/antidote-europe.eu\/wp-content\/uploads\/2013\/01\/danger-bisphenol21-300x169.png\" alt=\"danger bisphenol antidote europe\" width=\"300\" height=\"169\" \/>Bisphenol A (BPA) is a synthetic chemical composed of two phenol rings joined together by a carbon atom. It is\u00a0<strong>manufactured in huge quantities<\/strong>\u00a0(3 billion kg\/year) for use in the production of polycarbonate plastics (e.g. dummies, inside lining of tinned foods and beverages), as well as other industrial applications, such as the manufacture of\u00a0PVC\u00a0piping or flooring.<\/p>\n<p>BPA\u00a0is\u00a0<strong>leached fairly easily<\/strong>\u00a0from these plastic products when moistened (especially with hot water). It is also leached in the presence of detergents, acids, and greasy substances \u2014 including food. Although\u00a0BPA\u00a0is excreted fairly rapidly from the body, anyone living in a developed country consumes this substance unknowingly, virtually every day.\u00a0BPA\u00a0is therefore present in our body tissues in significant amounts, more so in women than men and more so in children than in adults.\u00a0BPA\u00a0is perhaps not overtly harmful in the short term, but its chemical structure does suggest that it could affect our health in the medium and long term.<\/p>\n<p>There is an abundance of scientific literature describing the effects of\u00a0BPA\u00a0in animal \u201cmodels\u201d but Antidote does not consider these studies to be relevant to human health, since no species can reliably substitute another when evaluating chemical toxicity.<\/p>\n<p>There are three relevant approaches:<\/p>\n<ul>\n<li>the study of human biological material;<\/li>\n<li>epidemiological (human population) studies;<\/li>\n<li>molecular studies, where the structure of test substances is compared with those of known biological activity in humans.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>As an early screening test, the science of toxicogenomics is ideally suited to the task at hand. Results can be obtained quickly, cost-effectively and are relevant to the species in question \u2014 humans.<\/p>\n<p>Several such studies are already in the public domain. One such study \u2014 commissioned by Antidote Europe \u2014 shows that\u00a0BPA\u00a0and its metabolites (breakdown products) significantly interfere with the ability of the cell to guard against oxidative stress, uncontrolled cell growth (cancer), excessive hormonal stimulation and incorrect protein folding. This type of cell damage increases the likelihood of so-called \u201cconformational\u201d diseases, including Parkinson\u2019s disease, Alzheimer\u2019s, and adult onset (type 2) diabetes. Other effects on the body include hormonal imbalances during sexual development and a decrease in male fertility. The data from our study has been duly logged in an international database.<\/p>\n<p>Additional studies with toxicogenomics and human cells, have shown that the oestrogenic effect of\u00a0BPA\u00a0is at least as powerful as the naturally occurring hormone, 17beta-estradiol, but that\u00a0BPA\u00a0and other estrogen-mimicking chemicals tend to amplify normal gene function associated with this hormone. Even tiny concentrations \u2014 which may have undetectable activity \u2014 are therefore sufficient to produce significant hormonal effects (leading to breast or prostate cancer) as well as genital malformations (1). These effects have been confirmed in human population studies (2-10).<\/p>\n<p>It is an established fact that chemicals resembling each other structurally will have similar biological properties (QSAR\u00a0concept). The compound\u00a0<strong>diethyl stilbestrol (DES)<\/strong>also has two phenol rings, joined by two carbon atoms (instead of just one in the case ofBPA). For a period of 30 years,\u00a0DES\u00a0was prescribed to pregnant women in France, as an aid to prevent abortion (but for which it was ineffective). A total of 200 000 women were exposed to this drug. It would take science 30 years to discover that this drug was teratogenic, producing serious birth defects (chiefly cervical cancer) in the daughters \u2014 and even the grand daughters \u2014 of these women. Since\u00a0BPA\u00a0and\u00a0DES\u00a0closely resemble each other structurally, it is very likely that they will have similar biological properties. The catastrophic effects of\u00a0DES\u00a0are documented in medical history for all to see.\u00a0<strong>There is now the grim possibility that we will face a\u00a0BPA\u00a0\u201ctime bomb\u201d sometime in the future.<\/strong>\u00a0Unlike\u00a0DES, it will be a much greater challenge to removeBPA\u00a0from our environment. Equally disturbing is the fact that not only pregnant women will be affected, but the entire population, especially young children. This represents an existentialist threat to the survival of the human species, where fertility in both sexes will be affected, in addition to causing an increase in diseases such as cancer, neurodegenerative conditions, diabetes, and many others.<\/p>\n<p><a href=\"https:\/\/antidote-europe.eu\/cp25aou08_gb.htm\">According to \u2018experts\u2019<\/a>\u00a0BPA\u00a0poses only a \u201cmild\u201d or \u201cinsignificant\u201d risk to humans, despite the fact that this chemical continues to build up in our bodies. These same experts also tell us that pregnant women and their unborn foetuses have nothing to fear because \u201cpregnant women rapidly metabolise and excrete this chemical\u201d. Surely these experts must know that the speed at which a substance is broken down and passed out of the body has nothing to do with its biological activity while it is inside the body? This is a basic principle of pharmacokinetics (drug action).<\/p>\n<p>France should respect the health of its citizens by following the example of Canada in 2008, and withdraw\u00a0BPA\u00a0from the market to protect the nation\u2019s health and future prosperity.<\/p>\n<h2>References:<\/h2>\n<ol>\n<li>\u201cConvergent transcription profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells\u201d, Buterin T., Koch C. &amp;H Naegeli, Carcinogenesis 2006, 27 : 1567-78.<\/li>\n<li>\u201cAssociation of urinary Bisphenol A concentration with medical disorders and laboratory abnormalities in adults\u201d. Lang IA, Galloway TS, Scarlett A et Als\u00a0JAMA, 2008;300:1303-1310.<\/li>\n<li>\u201cUrinary concentrations of bisphenol A and 4-nonylphenol in a human reference population.\u201d Calafat AM, Kuklenyik Z, Reidy JA, et al. Environ Health Perspect 2005 ; 113 : 391-5.<\/li>\n<li>\u201cPositive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction\u201d.Takeuchi T, Tsutsumi O, Ikezuki Y, Takai Y, Taketani Y, Endocr J, 2004;51:165-169.<\/li>\n<li>\u201cBisphenol-A disruption of the endocrine pancreas and blood glucose homeostasis\u201d Ropero AB, Alonso-Magdalena P, Garcia-Garcia E, Ripoll C, Fuentes E, Nadal A, Int J Androl, 2008;31(2):194-200.<\/li>\n<li>\u201cThyroid hormone action is disrupted by bisphenol A as an antagonist\u201d, Moriyama K, Tagami T, Akamizu T et als. J Clin Endocrinol Metab, 2002;87:5185-5190.<\/li>\n<li>\u201cBisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons\u201d. Le HH, Carlson EM, Chua JP, Belcher SM. Toxicol Lett. 2008 Jan 30;176(2):149-56.<\/li>\n<li>\u201cParental bisphenol A accumulation in the human maternal-fetal-placental unit\u201d, Sch\u00c3\u00b6nfelder G., Wittfoh W., Hopp H., Talsness CE., Paul M. &amp;Chahoud I. Env. Health Perspect 2002; 110: A703-7.<\/li>\n<li>\u201cMigration of bisphenol A from polycarbonate baby and water bottlesinto water under sever conditions\u201d Coa X.L. &amp; Corriveau J. J. Agric Food Chem 2008; 56: 6378-81.<\/li>\n<li>\u201cExposure to Bisphenol A and Other Phenols in Neonatal Intensive Care Unit Premature Infants\u201d Calafat AM &amp; al. 2009 Env. Health Perspect. 117: 639-44.<\/li>\n<\/ol>\n<!--themify_builder_content-->\n<div id=\"themify_builder_content-3764\" data-postid=\"3764\" class=\"themify_builder_content themify_builder_content-3764 themify_builder tf_clear\">\n    <\/div>\n<!--\/themify_builder_content-->\n","protected":false},"excerpt":{"rendered":"<p>Bisphenol A (BPA) is a synthetic chemical composed of two phenol rings joined together by a carbon atom. It is\u00a0manufactured in huge quantities\u00a0(3 billion kg\/year) for use in the production of polycarbonate plastics (e.g. dummies, inside lining of tinned foods and beverages), as well as other industrial applications, such as the manufacture of\u00a0PVC\u00a0piping or flooring&#8230;. <a href=\"https:\/\/antidote-europe.eu\/en\/danger-bisphenol\/\"><i>Read more<\/i><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3764","page","type-page","status-publish","hentry","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Danger Bisphenol ! - Antidote Europe<\/title>\n<meta name=\"description\" content=\"Bisphenol A (BPA) is a synthetic chemical composed of two phenol rings joined together by a carbon atom. 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