Dear Professor Buzek,<\/p>\n
May I sincerely congratulate you on your new position as president of the European Parliament and may your term as president be a successful and fulfilling one. I am writing to you, not only as a concerned EU citizen, but as a fellow scientist. The fact that you are a chemical engineer by profession means that you are familiar with the problem of\u00a0bisphenol A (BPA) and its effects on human health<\/strong>. You are also certainly aware of the close structural resemblance between\u00a0BPA\u00a0and another, more potent chemical, diethyl stilbestrol (DES), whose disastrous health consequences have been well documented.<\/p>\n Our organisation, Antidote Europe, would like to bring to your attention the sensible decision of the Canadian government in 2008 to declare\u00a0BPA\u00a0a dangerous substance and to ban it in baby bottles. Equally important, I would like to refer you to\u00a0studies involving human data<\/strong>\u00a0and developmental biology, which should be taken into account with respect to regulatory decision-making in the EU, in particular by the European Food Safety Authority (EFSA). These include\u00a0BPA\u00a0levels in human umbilical cord blood samples as well as other biological fluids, epidemiological studies and results obtained using toxicogenomics (see\u00a0https:\/\/antidote-europe.eu\/cp08jul09_gb.htm<\/a>). Standard toxicological studies involving animal data and linear relationships are inappropriate when considering the effects of\u00a0BPA\u00a0in relation to the human foetus.<\/p>\n It is unfortunate that some sectors of industry and even some sectors of the regulatory apparatus choose to put human health at risk, on the basis of irrelevant or selective data. Antidote Europe, together with like-minded consumer and environmental protection organisations, succeeded in getting the concept of \u201ctoxicogenomics\u201d included in theREACH\u00a0regulations and approved by the Council of Ministers. Sadly, the EU still lags significantly behind the US in the application of toxicogenomics as an early screening tool to assess the toxic risk potential of the 100,000 chemicals in which we live today. The use of modern toxicology, in combination with the field of developmental biology, will continue to provide valuable information to health authorities concerning\u00a0BPA. We trust that you will give your full consideration to this information with regard to the health of EU citizens.<\/p>\n Respectfully yours,<\/p>\n Claude Reiss PhD<\/em> Andre Menache\u00a0MRCVS<\/em> Antidote Europe is a non-profit association created by scientists and researchers working towards biomedical research methods that represent sound science.<\/p>\n 1.<\/b>\u00a0http:\/\/www.hc-sc.gc.ca\/ahc-asc\/media\/nr-cp\/_2008\/2008_167-eng.php<\/a>\u00a0 2.<\/b>\u00a0Ikezuki Y et al.\u00a0Hum Reprod<\/i>\u00a02002 Nov;17(11):2839-41. \u201cDetermination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure\u201d<\/p>\n 3.<\/b>\u00a0vom Saal et al.\u00a0Environ Res<\/i>\u00a02006 Jan, 100:50-76 \u201cLarge effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A\u201d<\/p>\n 4.<\/b>\u00a0Calafat AM et al.\u00a0Environ Health Perspect<\/i>\u00a02005; 113: 391-5 \u201cUrinary concentrations of bisphenol A and 4-nonylphenol in a human reference population.\u201d<\/p>\n 5.<\/b>\u00a0Takeuchi T et al.\u00a0Endocr J<\/i>, 2004;51:165-169. \u201cPositive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction\u201d.<\/p>\n 6.<\/b>\u00a0Ropero AB et al.\u00a0Int J Androl<\/i>, 2008;31(2):194-200 \u201cBisphenol-A disruption of the endocrine pancreas and blood glucose homeostasis\u201d<\/p>\n 7.<\/b>\u00a0Moriyama K et al.\u00a0J Clin Endocrinol Metab<\/i>, 2002;87:5185-5190 \u201cThyroid hormone action is disrupted by bisphenol A as an antagonist<\/p>\n 8.<\/b>\u00a0Le HH et al.\u00a0Toxicol Lett.<\/i>\u00a02008 Jan 30; 176(2):149-56 \u201cBisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons\u201d.<\/p>\n 9.<\/b>\u00a0Vandenberg LN et al. Bisphenol-A and the great divide : a review of controversies in the field of endocrine disruption.\u00a0Endocr Rev.<\/i>\u00a02009 Feb; 30(1):75-95<\/p>\n 10.<\/b>\u00a0Calafat AM et al. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol : 2003-2004.\u00a0Environ Health Perspect<\/i>. 2008 Jan;116(1):39-44<\/p>\n 11.<\/b>\u00a0Myers JP et al. Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data : the case of bisphenol A.\u00a0Environ Health Perspect<\/i>. 2009 Mar;117(3):309-15<\/p>\n 12.<\/b>\u00a0Bouskine A, et al. 2009. Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating\u00a0PKA\u00a0and\u00a0PKG\u00a0via a Membrane G protein-coupled Estrogen Receptor\u00a0Environ Health Perspect<\/i>\u00a0: doi : 10.1289\/ehp.0800367.(Online 11 February 2009)<\/p>\n 13.<\/b>\u00a0La Pensee EW et al. Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-&-positive and-negative breast cancer cells.\u00a0Environmental Health Perspectives<\/i>\u00a0Volume 117, Number 2, February 2009<\/p>\n 14.<\/b>\u00a0Hess-Wilson JK. Bisphenol A may reduce the efficacy of androgen deprivation therapy in prostate cancer.\u00a0Cancer Causes Control<\/i>\u00a0DOI\u00a010.1007\/s10552-009-9337-8.<\/p>\n 15.<\/b>\u00a0Lang IA, Galloway TS, Scarlett A; et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults.\u00a0JAMA<\/i>. 2008;300(11):1303-1310.<\/p>\n 16.<\/b>\u00a0Wetherill YB, et al. In vitro molecular mechanisms of bisphenol A action.\u00a0Reprod Toxicol<\/i>. 2007;24(2):178-198.<\/p>\n 17.<\/b>\u00a0Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA).\u00a0Reprod Toxicol<\/i>. 2007;24(2):139-177.<\/p>\n 18.<\/b>\u00a0Stahlhut RW, et al. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males.\u00a0Environ Health Perspect<\/i>. 2007;115(6):876-882.<\/p>\n 19.<\/b>\u00a0Bindhumol V, et al. Bisphenol A induces reactive oxygen species generation in the liver of male rats.\u00a0Toxicology<\/i>. 2003;188(2-3):117-124.<\/p>\n 20.<\/b>\u00a0Alonso-Magdalena P, et al. Pancreatic insulin content regulation by the estrogen receptor ER alpha.\u00a0PLoS\u00a0ONE<\/i>. 2008;3(4):e2069.<\/p>\n 21.<\/b>\u00a0Hugo ER, et al. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes [published online August 14, 2008].\u00a0Environ Health Perspect<\/i>. doi:10.1289\/ehp.11537.<\/p>\n 22.<\/b>\u00a0Welshons WV, et al. Large effects from small exposures,\u00a0III: endocrine mechanisms mediating effects of bisphenol A at levels of human exposure.\u00a0Endocrinology<\/i>. 2006;147(6)(suppl):S56-S69.<\/p>\n 23.<\/b>\u00a0vom Saal FS, et al. Bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure.\u00a0Reprod Toxicol<\/i>. 2007;24(2):131-138.<\/p>\n 24.<\/b>\u00a0Rapport d\u2019analyse complet du National Toxicology Program sur le\u00a0BPA<\/p>\n 25.<\/b>\u00a0European Food Safety Authority. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2,2-HYDROXYPHENYL”>BIS<\/acronym>PROPANE\u00a0(Bisphenol A).\u00a0EFSA\u00a0J<\/i>. 2006;428:1-76.<\/p>\n 26.<\/b>\u00a0Statement of Norris Alderson. PhD, Associate Commissioner for Science, Food and Drug Administration, Department of Health and Human Services, before the Subcommittee on Commerce, Trade and Consumer Protection, Committee on Energy and Commerce, US House of Representatives. US Food and Drug Administration Web site.\u00a0http:\/\/www.fda.gov\/ola\/2008\/BPA061008.html<\/a>\u00a0 27.<\/b>\u00a0Lee DS, et al. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.\u00a0Arterioscler Thromb Vasc Biol<\/i>. 2007;27(1):127-133.<\/p>\n 28.<\/b>\u00a0vom Saal FS, Hughes C. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment.\u00a0Environ Health Perspect<\/i>. 2005;113(8):926-933.\u00a0ISI\u00a0|\u00a0PUBMED<\/p>\n 29.<\/b>\u00a0Michaels D. Doubt Is Their Product: How Industry\u2019s Assault on Science Threatens Your Health. New York, NY: Oxford University Press; 2008.<\/p>\n 30.<\/b>\u00a0De Ferranti SD, Osganian SK. Epidemiology of paediatric metabolic syndrome and type 2 diabetes mellitus.\u00a0Diab Vasc Dis Res<\/i>. 2007;4(4):285-296.<\/p>\n 31.<\/b>\u00a0Newbold RR, et al. Effects of endocrine disruptors on obesity.\u00a0Int J Androl<\/i>. 2008;31(2):201-208.<\/p>\n 32.<\/b>\u00a0Prins GS, et al. Developmental estrogen exposures predispose to prostate carcinogenesis with aging.\u00a0Reprod Toxicol<\/i>. 2007;23(3):374-382.<\/p>\n 33.<\/b>\u00a0Anastas PT, Beach ES. Green chemistry: the emergence of a transformative framework.\u00a0Green Chem Let Rev<\/i>. 2007;1(1):9-24.<\/p>\n 34.<\/b>\u00a0Buterin T., Koch C. &H Naegeli, Convergent transcription profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells\u00a0Carcinogenesis<\/i>2006, 27 : 1567-78.<\/p>\n 35.<\/b>\u00a0Evaluation de la toxicit\u00c3\u00a9 de\u00a028 substances<\/a>\u00a0chimiques de synth\u00c3\u00a8se (resultats d\u2019analyses toxicog\u00c3\u00a9nomique men\u00c3\u00a9es par Antidote Europe)<\/p>\n 36.<\/b>\u00a0Beronius A et al.\u00a0Regul Toxicol Pharmacol<\/i>. 2009 Jun 13. \u201cHealth risk assessment procedures for endocrine disrupting compounds within different regulatory frameworks in the European Union\u201d<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
\nPresident, Antidote Europe
\nFormer departmental head at the French Centre National de Recherche Scientifique (CNRS)<\/p>\n
\nDirector, Antidote Europe
\nVeterinary surgeon<\/p>\nReferences<\/h2>\n
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<\/p>\n\u00a0June .10, 2008. Accessed August 12, 2008.<\/p>\n